Interleukin-12 (IL-12), produced by dendritic cells in response to activation, is central to pathogen eradication and tumor rejection.The trafficking pathways controlling spatial distribution and intracellular transport of IL-12 vesicles to the cell surface are still unknown.Here, we show that intracellular IL-12 localizes in late endocytic vesicle
First isolated in 1947 from a monkey in the Zika forest in Uganda, and from mosquitoes in the same forest the following year, Zika virus has gained international attention due to concerns for infection in pregnant women potentially causing fetal microcephaly.More than one million people have been infected since the appearance of the virus in Brazil
ABSTRACT Timeliness of financial statements publication or referred to audit delay is the length of the completion time of the audit as measured from the date of the closing fiscal year until the date of the issuance of audit reports.This research aimed to investigate the effect of auditor characteristics (age, education level, experience) and type
This article examines the problematic processes in a case that has had few parallels in Indian judicial history.The apex court in T.N.Godavarman took upon the responsibility of deciding how forest resources in the country should be accessed and who is (or is not) to have such access.Purportedly done to protect the environment, through the ′c
A tube-integrated flow sensor is proposed in this study by integrating a micro-electro mechanical systems (MEMS) flow-sensing element and electrical wiring structure on the same copper on polyimide (COP) substrate.The substrate was rolled into a circular tube with the flow-sensing element Heel Support installed at the center of the tube.The signal